The Orange County Sheriff's Department holds a DUI/driver license checkpoint in Dana Point from 6 tonight through 3 a.m. Saturday.
The exact location of the operation has not been released.
Deputies will check drivers for signs of alcohol and/or drug impairment as well as proper licensing.
Collisions involving DUI have claimed 21 lives and resulted in 497 injuries within the Orange County Sheriff's Department jurisdiction over the past three years, according to Deputy Shane Stewart of the sheriff's Traffic Bureau.
Checkpoint funding comes from a California Office of Traffic Safety grant, through the National Highway Traffic Safety Administration.